No Normalization of Hypocretin-1 Deficiency or Narcoleptic Phenotype after Early Ivig Treatment in Post-h1n1 Vaccination Narcolepsy with Cataplexy
نویسندگان
چکیده
P1730 NO NORMALIZATION OF HYPOCRETIN-1 DEFICIENCY OR NARCOLEPTIC PHENOTYPE AFTER EARLY IVIG TREATMENT IN POST-H1N1 VACCINATION NARCOLEPSY WITH CATAPLEXY S. Knudsen1, B. Biering-Sørensen2, J.D. Ibsen1, E.R. Petersen1, S. Gammeltoft3, P. Jennum1 1Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, 2Department of Neurology, 3Department of Clinical Biochemistry, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
منابع مشابه
CSF hypocretin-1 levels in narcolepsy, Kleine-Levin syndrome, and other hypersomnias and neurological conditions.
OBJECTIVE To determine the role of CSF hypocretin-1 in narcolepsy with and without cataplexy, Kleine-Levin syndrome (KLS), idiopathic and other hypersomnias, and several neurological conditions. PATIENTS 26 narcoleptic patients with cataplexy, 9 narcoleptic patients without cataplexy, 2 patients with abnormal REM-sleep-associated hypersomnia, 7 patients with idiopathic hypersomnia, 2 patients...
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STUDY OBJECTIVES Cerebrospinal fluid (CSF) hypocretin-1 levels and their relationship with the clinical characteristics of narcolepsy without cataplexy have not been well elucidated. Our aim was to examine whether clinical characteristics vary with CSF hypocretin-1 levels among narcoleptic patients without cataplexy. DESIGN Clinical features, variables on the multiple sleep latency test, and ...
متن کاملNarcolepsy as an Immune-Mediated Disease
Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness, cataplexy, hypnagonic hallucinations, sleep paralysis, and disturbed nocturnal sleep patterns. This disease is secondary to the specific loss of hypothalamic hypocretin (orexin)-producing neurons in the lateral hypothalamus. An autoimmune basis for the disease has long been suspected based on its strong associa...
متن کاملPost-H1N1 Flu Vaccination Narcolepsy in Switzerland: A Retrospective Survey in the 30 Sleep-Certified Swiss Centers.
Narcolepsy-cataplexy is a sleep-wake disorder and suggested to be immune-mediated, involving genetic and environmental factors. The autoimmune process eventually leads to a loss of hypocretin neurons in the lateral hypothalamus. Epidemiological studies in several countries proved an increased incidence of narcolepsy after H1N1 flu vaccination and infection. This survey in 30 sleep centers in Sw...
متن کاملHypocretin deficiency develops during onset of human narcolepsy with cataplexy.
STUDY OBJECTIVES Although hypothesized through animal studies, a temporal and causal association between hypocretin deficiency and the onset of narcolepsy with cataplexy (NC) has never been proven in humans. SETTING Paediatric Department, Blekinge Hospital, Sweden, and Danish Center for Sleep Medicine, Glostrup Hospital, Denmark. PATIENT AND RESULTS Two weeks after his second Pandemrix-vacc...
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